Stress Response, Tachykinin, and Cutaneous Inflammation
نویسندگان
چکیده
منابع مشابه
Substance P induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice.
Our experiments were conducted to determine whether substance P (SP) would elicit an itch sensation mediated by mast cells in mice. An intradermal injection of SP (10-135 microgram site-1) into the rostral back of the ICR mouse dose-dependently produced scratching of the injected site. The SP- (135 microgram site-1 = 100 nmol site-1) induced scratching was inhibited by capsaicin (repeated admin...
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Tachykinins represent a family of peptides which have significant effects on such diverse physiological responses as gut peristalsis, vascular permeability, and the transmission of pain. Traditionally, neurons have been identified as the major source of tachykinin peptides in peripheral tissues and in the central nervous system, resulting in their classification as neuropeptides or, more specif...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology Symposium Proceedings
سال: 2001
ISSN: 1087-0024
DOI: 10.1046/j.0022-202x.2001.00015.x